Digoxin is a medication used to treat various heart conditions. Digoxin is derived from the species Digitalis lanata and was first described by William Withering in 1785.
Nowadays, the only clinical indication for digoxin use is atrial fibrillation with rapid ventricular response. Very rarely might be used as an inotropic agent in patients with heart failure as a third-line therapy.
negative chronotropic → slows down the heart rate
negative dromotropic → slows conduction over the AV node
positive inotropic → enhance myocardial contraction (increases the amount of calcium in the heart’s cells)
Digoxin therapeutic window
level > 2ng/ml is toxic and increases the likelihood of arrhythmias