Pancuronium (Pavulon)

Mechanism of action

Non-depolarising neuromuscular blocker (long acting).

Blocks neuromuscular transmission by competitive inhibition of nicotinic acetylcholine receptors on the motor end-plate. 

Indications and dose


Onset of action: 2–3 minutes

Duration of action: 45–60 minutes

Half-life of elimination: approx. 2 hours

Metabolism: Hepatic

Elimination: Kidneys

Directions for administration

For intravenous administration. 

Not recommended to be given by infusion.

Medicinal forms

Solution for injection (2 mg/ml)

1 vial = 2 ml (4 mg)


Moderate tachycardia and increased cardiac output


Rapid reversal of pancuronium is achieved by anticholinesterase agents.

See more about it in Neostigmine list.


  1. Pharm 101: Pancuronium • LITFL • Top 200 Drugs
  2. Pancuronium Bromide 2 mg/ml Injection - Summary of Product Characteristics (SmPC) - (emc) (
  3. Pancuronium: Uses, Interactions, Mechanism of Action | DrugBank Online
  4. Pancuronium Monograph for Professionals -