Ivabradine (Corlanor, Procoralan)

Mechanism of action

Selectively inhibits If channels (“funny channels”) in sinoatrial node which prolongs diastolic depolarization of pacemaker and thus lowers heart rate and reduces myocardial oxygen demand, therefore angina pectoris symptoms. 

Indications and dose


Onset of action: 1 hour

Duration of action: 11 hours effective half life

Half-life of elimination: 2 hours

Metabolism: Extensive gut and hepatic (CYP 3A4) metabolism

Elimination: Kidneys and liver equally

Directions for administration

Patients should not drink grapefruit juice while taking this medication.

Taking ivabradine with food is recommended as it increases its absorption by 20–30 %.

Pills are to be taken orally twice daily.

Medicinal forms

Pills – 5 mg, 7.5 mg



Luminous phenomena (phosphenes)

1st degree AV block

Ventricular extrasystoles

Atrial fibrillation

Blurred vision

Headache, dizziness


  1. Ivabradine 2.5 mg film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc) (medicines.org.uk)
  2. Ivabradine: Uses, Interactions, Mechanism of Action | DrugBank Online
  3. Ivabradine (Corlanor) for Heart Failure: The First Selective and Specific If Inhibitor - PMC (nih.gov)