Protamine

Mechanism of action

Reversal agent of heparin.

As a highly alkaline protein binds to strongly acidic heparin and forms stable salt, neutralising its anticoagulant effect.

Indications and dose

Side-effects

Non-cardiogenic pulmonary edema

Hypersensitivity reactions

Pharmacokinetics

Routes: Intravenous

Onset: 5 minutes

Half-life of elimination: 7 minutes

Directions for administration

For intravenous use do not exceed rate of 50 mg/10 minutes for hypotension + possible anticoagulant effect.

Medicinal forms

Solution for injection

1 vial = 25 ml (250 mg)

1 vial = 5 ml (50 mg)

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References

https://litfl.com/protamine/ 

https://bnf.nice.org.uk/drugs/protamine-sulfate/ 

https://www.uptodate.com/contents/protamine-sulfate-drug-information?search=protamine&source=panel_search_result&selectedTitle=1~116&usage_type=panel&kp_tab=drug_general&display_rank=1