Mechanism of action
Antiplatelet agent.
Reversibly inhibits glycoprotein IIb/IIIa on platelets which prevents platelet aggregation. GP IIb/IIIa is a receptor for fibrinogen and von Willebrand factor and is essential in platelet aggregation and activation.
Indications and dose
Pharmacokinetics
Onset of action: Immediate
Duration of action: 6–8 hours after termination of infusion
Half-life of elimination: 2.5 hours
Metabolism: Deamination in plasma
Elimination: Kidneys
Medicinal forms
Solution for injection – 2 mg/ml
- 1 vial = 10 ml (20 mg)
Solution for infusion – 0.75 mg/ml
- 1 vial = 100 ml (75 mg)
Side-effects
Bleeding
Anaemia, thrombocytopenia
Cerebral hemorrhage
References
